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The effects of long-term reduction of short wavelength light in humans.

The effects of long-term reduction of short wavelength light on circadian regulation, neural aspects of cognitive and affective functioning in humans - a behavioural, questionnaire, actigraphy, biochemical and neuroimaging study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN18109340
Enrollment
60
Registered
2019-05-03
Start date
2015-05-05
Completion date
Unknown
Last updated
2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Participants were young, healthy volunteers. Not Applicable

Interventions

The study concerns young healthy volunteers, which were asked to wear blue light blocking lenses for the period of four weeks. Their functioning under the condition of blocking the blue light was comp

Sponsors

Narodowe Centrum Nauki
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age: 20-35 years old 2. Handedness: right 3. Regular sleep-wake cycle and sleep time between 6 and 9 hours per night 4. Experience in contact lens wearing (especially monthly disposable contact lenses without necessity to remove them for night) 5. Low level of daytime sleepiness, good sleep quality and non-extreme chronotype (on the basis of questionnaires).

Exclusion criteria

Exclusion criteria: 1. Any MR exclusion criteria (metal parts in the body, pacemaker, etc.) 2. Pregnancy 3. Chronic diseases (eg diabetes), neurological and psychiatric conditions. 4. Other than myopia eye conditions.

Design outcomes

Primary

MeasureTime frame
Measured at baseline and 6-weeks: 1. Brain activations involved in cognitive task - that is performance and neuronal activity for two cognitive tasks measured using fMRI 2. Brain activations involved in emotional task - neuronal activity measured using fMRI during presentation of emotionally positive and negative stimuli 3. Performance in cognitive tasks directed to measure alertness, working memory and visuo-spatial memory.

Secondary

MeasureTime frame
Measured at baseline and 6-weeks: 1. Sleep quality measurement - assessed with subjective sleep quality questionnaires (PSQI - Pittsburgh Sleep Quality Index and ESS - Epworth Sleepiness Scale ) in different experimental conditions; 2. Circadian rhythm measurement - assessed with diurnal salivary cortisol pattern (morning and evening levels) and DLMO (dim light melatonin onset, five samples taken each session); 3. Sleep-wake cycle assessed with the use of actigraphs; 4. Emotional functioning - assessed with mood questionnaires (positive and negative affectivity and hedonic tone). Questionnaires used: PANAS - Positive and Negative Affect Schedule and SHAPS - Snaith-Hamilton Pleasure Scale.

Countries

Poland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026