Routine general anaesthesia Surgery Anaesthesia
Conditions
Interventions
After pre-oxygenation, patients will be randomised to one of three groups for the administration of either: suxamethonium 1 mg/kg, rocuronium 1 mg/kg followed by sugammadex 10 mg/kg or rocuronium 1 mg
0.9% saline will be administered at this time in the suxamethonium group to maintain blinding.
Sponsors
Belfast Health and Social Care Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. American Society of Anaesthesiologists (ASA) class I - III 2. Patients able to give written informed consent 3. Patients requiring general anaesthesia 4. Patients aged 18 - 65 years, either sex
Exclusion criteria
Exclusion criteria: 1. History of dementia or difficulty in providing informed consent 2. Patients with chronic obstructive pulmonary disease (COPD) 3. Patients with a history of ischaemic heart disease (IHD) 4. Patients with a haemoglobin concentration of less than 10 g/dl 5. Patients with a history of known difficulty in intubation or with an anticipated challenging airway 6. Pregnancy 7. Patients with a history of allergy to any of the medications used in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of time to resumption of spontaneous ventilation as indicated by visible diaphragmatic movement or decrease in oxygen saturation to less than or equal to 90% before onset of spontaneous ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Frequency of desaturation to less than or equal to 90% 2. Length of time to movement of reservoir bag 3. Length of time to first capnographic evidence of ventilation 4. Incidence of adverse events in all groups | — |
Countries
United Kingdom
Outcome results
None listed