Biomarkers of enteropathy in infants and children with severe acute malnutrition in Nigeria

Non-invasive biomarkers of enteropathy in infants and children with severe acute malnutrition: A pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18078424

Enrollment

100

Registered

2016-04-29

Start date

2012-07-01

Completion date

Unknown

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe acute malnutrition (SAM) Nutritional, Metabolic, Endocrine Severe acute malnutrition (SAM)

Interventions

For the participants, demographic and clinical data and a blood sample will be collected at recruitment. Demographic and clinical data will be collected onto standard forms and include information obt

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients: Children aged 6 – 59 months admitted with SAM (WHZ 12.5 cms or WHZ score = -1 and no nutritional oedema)

Exclusion criteria

Exclusion criteria: Positive for HIV

Design outcomes

Primary

Measure	Time frame
1. Untargeted multi-platform metabolomics (gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry) in stool (first available sample) and plasma sample (at recruitment) 2. Faecal volatile organic metabolites in headspace gas from first available stool sample 3. Intesinal inflammation by measuring stool calprotectin and lactoferrin in first available stool sample	—

Secondary

Measure	Time frame
Stool microbiota composition is measured using 16S rRNA gene sequencing in the first available stool sample.	—

Countries

Nigeria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026