Tongue-preserving treatment using brachytherapy and intensity-modulated radiation therapy technique for localized tongue cancer

Hybrid brachytherapy followed by intensity-modulated radiation therapy (HyBIRT) technique for the definitive management of localized tongue cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18070464

Enrollment

100

Registered

2026-04-13

Start date

2021-10-11

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tongue squamous cell cancer (TSCC) Cancer

Interventions

The HyBIRT technique involves: 1. Upfront interstitial brachytherapy to tongue tumor 20 Gy in 5F 2. Adoptive intensity modulated radiation therapy (IMRT) to the tongue and neck (56.1 Gy - 69.96 Gy in

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients with histology-confirmed TSCC 2. Tumor limited to anterior 2/3 (mobile tongue), TNM7 stage T1-4a, N1-2c, M0 3. Refused surgery or unfit for surgery 4. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2

Exclusion criteria

Exclusion criteria: 1. Tumor involving the posterior third of the tongue 2. Radiologically confirmed metastatic disease (M1) 3. Contraindication for nasal intubation 4. ECOG Performance Status 3-4

Countries

Malaysia

Contacts

Public ContactGokula Kumar Appalanaido

gokula@usm.my+60 (0)45622701

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 1, 2026