Chronic Obstructive Pulmonary Disease Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
Arm A: receive vitamin C supplement (500 mg) effervescent pills orally, once per day for 6 months
Arm B: receive NAC (600 mg) effervescent pills orally, once per day for 6 months
Arm C: receive combin
Sponsors
National University of Malaysia (Universiti Kebangsaan Malaysia) (Malaysia)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. An established clinical history of COPD diagnosed by the physician, with pre-bronchodilator forced expiratory volume in 1 second (FEV1) % predicted 30?80%, which was defined as stage I, II and III based on the American Thoracic Society (2004) definition. 2. Patients aged between 35 to 75 years old who did not take any antioxidant supplementation for the past three months, not diagnosed with co-morbidities such as diabetes mellitus (DM), tuberculosis (TB), and inflammatory disease, and had not been hospitalized for the past three months prior to the study
Exclusion criteria
Exclusion criteria: 1. Patients with co-morbidities such as diabetes mellitus (DM), tuberculosis (TB) and inflammatory disease and taking about 500 mg vitamin C through their diet or vitamin C supplements 2. The patients who took drugs such as aspirin, estrogen, amphetamine and cholesyramine regularly for the past three months which affected absorption of vitamin C
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Anthropometry 2. Food record 3. Body composition 4. Spirometry 5. Plasma antioxidants 6. Plasma oxidative stress biomarkers Measured at baseline and every 3 months (month 3 and month 6) of the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Malaysia
Outcome results
None listed