Screening for renal cell carcinoma (RCC) in participants of the Yorkshire Lung Screening Trial Cancer
Conditions
Interventions
Participants taking part in the study will be offered a non-abdominal CT scan at their T2 (2 years after baseline) YLST study visit.
Participants taking part in the Yorkshire Lung Screening Trial (Y
Sponsors
University of Leeds
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study is only open to participants of the Yorkshire Lung Screening Trial who are high risk for lung cancer as defined by one of the three criteria: 1. 30 pack year history of smoking and current smoker or quit within the last 15 years (USPSTF criteria) 2, Lung cancer risk of =1.51% over 6 years as calculated by the PLCOM2012 score 3. Lung cancer risk of =5% over 5 years as calculated by the LLPv2. score)
Exclusion criteria
Exclusion criteria: 1. Have undergone CT Thorax within the previous 12 months 2. Unable to provide informed consent to study 3. Unable to have a chest or abdominal non-contrast CT scan 4. Previous diagnosis of kidney cancer 5. Have undergone abdominal CT scan in previous 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The proportion of individuals attending the T2 round of YLST who take up the offer of an abdominal CT scan measured using patient records, reports and study visit logs. Calculated at a single time point 2. The acceptability to participants of combined lung and RCC screening by non-contrast CT scanning measured using interviews within 3 months of the invitation to the study 3. The acceptability to healthcare professionals involved in the screening of combining RCC screening by non-contrast CT scanning with lung cancer screening measured using interviews within 6 months of study start 4, The additional time required for the combined screening approach, including the time to provide information, consent participants, and perform the lengthier CT scan, the time needed by radiologists for reporting the CT scans, and the additional time to review abdominal CT findings measured using timing sheets at a single time point | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 04/02/2022: 1. The proportion of participants found to have a renal mass or RCC measured using CT at a single time point 2. The stage distribution of RCC identified through non-contrast CT screening at a single time point 3. The proportion of participants found to have incidental renal findings (cysts, anatomical variants) on non-contrast CT scanning at a single time point 4. The proportion of participants with non-renal findings i.e. abdominal aortic aneurysms, pancreatic and liver lesions on non-contrast CT scanning at a single time point 5. The proportion of RCCs found on the upper pole of participants in T2 who did not have them in the T0 round, to estimate the incidence of RCC over sequential non-contrast LDCT scans Previous secondary outcome measures: 1. The proportion of participants found to have an RCC measured using CT at a single time point 2. The stage distribution of RCC identified through non-contrast CT screening at a single time point 3. The proportion of participants found to have incidental renal findings (cysts, anatomical variants) on non-contrast CT scanning at a single time point 4. The proportion of participants with non-renal findings i.e. abdominal aortic aneurysms, pancreatic and liver lesions on non-contrast CT scanning at a single time point | — |
Countries
England, United Kingdom
Contacts
Public ContactJessica Kitt
Outcome results
None listed