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Testing a new approach for modifying the characteristics of the gums

Clinical comparative study of autologous albumin gel mixed with liquid platelet-rich fibrin (Alb-PRF) vs connective tissue graft to modify the gingival phenotype

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN18042063
Enrollment
20
Registered
2023-04-24
Start date
2021-09-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin gingival phenotype Oral Health

Interventions

In this split-mouth study, individuals with thin gingival phenotypes were randomly treated with a connective tissue graft and an albumin gel-platelet-rich fibrin mixture (Alb-PRF). Allocation will be

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients 2. Gingival thickness of the mandibular anterior teeth >1 mm 3. No pregnancy or lactation 4. Non-smokers 5. Adequate plaque control 6. At least 18 years of age 7. No previous periodontal surgery in the area

Exclusion criteria

Exclusion criteria: 1. Active orthodontic treatment 2. Previous periodontal surgery 3. Use of any drug that might affect periodontal health 4. Malocclusion, crowding, missing or supernumerary teeth 5. Tooth mobility, bruxism 6. Patients with a history of malignancy, radiotherapy, or chemotherapy for malignancy

Design outcomes

Primary

MeasureTime frame
1. Gingival thickness measured using a no.15 endodontic spreader (inserted perpendicularly from the vestibular midpoint 1.5 mm apical of the gingival margin through the soft tissue until a hard surface is reached) and a digital caliper to assess the penetration depth at baseline, 1, and 3 months 2. Keratinized tissue width measured from gingival margin to mucogingival junction with the help of a periodontal probe (UNC 15 probe) at baseline, 1, and 3 months

Secondary

MeasureTime frame
1. Probing depth index measured using a periodontal probe to measure the periodontal pocket depth at baseline, 1, and 3 months 2. Relative attachment level measured using a UNC-15 probe at baseline, 1 and 3 months 3. Pain measured using a visual analogue scale (VAS) at 1 week after surgery 4. Healing measured using a healing index at 1, 2 weeks and 1 month after surgery

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026