SAGA-trial - investigating if intraoperative sterile water irrigation during an operation to remove the kidney due to cancer (nephroureterectomy for upper tract urothelial carcinoma) decreases the risk of tumor recurrence.

Sterile water irrigation at nephroureterectomy for upper tract urothelial carcinoma: a study on the effect on bladder tumour recurrence

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN18038733

Enrollment

200

Registered

2021-10-07

Start date

2021-10-01

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper tract urothelial carcinoma Cancer

Interventions

Control arm = no additional treatment during nephroureterectomy Intervention arm = sterile water irrigation during nephroureterectomy Randomization by sealed envelopes Follow up for 2 years

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 18 years old or above 2. Upper tract urothelial carcinoma treated by nephroureterectomy.

Exclusion criteria

Exclusion criteria: 1. Lack of informed consent 2. Below 18 years of age

Design outcomes

Primary

Measure	Time frame
Bladder cancer recurrence measured by cystoscopy up to 2 years after the operation	—

Secondary

Measure	Time frame
1. Quality of life assessed by EORTC QLQ 30 NMIBC six weeks after nephroureterectomy 2. Bladder cancer progression free survival as assessed at end of 2 years 3. Quality of life measured using EQ-5D-5L at six weeks after nephroureterectomy	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026