Immune function of sepsis patients in intensive care and intermediate care units

Immune profiling of sepsis patients in intensive care and intermediate care units

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN18031817

Enrollment

300

Registered

2026-01-15

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Suspected sepsis with organ dysfunction in adult patients admitted to intensive care or intermediate care units. Infections and Infestations

Interventions

This is a prospective observational cohort study conducted at Karolinska University Hospital (Solna and Huddinge), Danderyds Hospital, and Södersjukhuset, Stockholm, Sweden. Adult patients are enrolle

healthy controls are sampled using corresponding procedures. Whole blood is stabilised/cryopreserved and analysed using multiparameter, high-dimensional flow cytometry with specific immune cell panels

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age: =18 years. 2. Setting: Admitted to an intensive care unit (ICU) or intermediate care unit (IMCU/intermediate care). 3. Condition: Suspected sepsis, defined as suspected/probable infection treated with antimicrobial therapy and at least one acute organ dysfunction requiring organ support. 4. Sampling feasibility: Ability to provide study blood samples according to protocol. 5. Consent: Informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Previously included in the same study. 2. Moribund patient. 3. Informed consent for participation not obtained.

Countries

Sweden

Contacts

Public ContactKristoffer Strålin

kristoffer.stralin@ki.se+46 70 5927532

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026