Root coverage with Emdogain versus root coverage with cross-linked hyaluronic acid

Root coverage with adjunctive enamel matrix derivative vs. cross-linked hyaluronic acid: 6-months, blinded RCT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17988982

Enrollment

Registered

2024-11-22

Start date

2024-11-21

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival recession coverage treatment Oral Health

Interventions

The study will include patients presenting with gingival recessions classified as RT1-2 (Cairo, 2011) or Miller Class I-III (Miller, 1985) on maxillary or mandibular teeth. A total of 60 recession def

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with RT1-2 or Miller 1-3, gingival recessions on maxillary or mandibular teeth 2. Aged between 18-70 years old 3. In good general health 4. Non-smokers or smoking up to 10 cigarettes/day

Exclusion criteria

Exclusion criteria: 1. Systemic diseases affecting periodontal health 2. Without periodontal active disease 3. Smoking above 10 cigarettes/day 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
Percentage of root coverage measured using a periodontal probe (PCP-UNC15 HuFriedy ) with a consistent reference point (CEJ) measured to the gingival margin position at 6 months post-surgery	—

Secondary

Measure	Time frame
1. Clinical attachment level gain will be assessed through the following measures: 1.1. Probing depth measured using a periodontal probe (PCP-UNC15 HuFriedy ) with a consistent reference point (CEJ) measured to the gingival margin position at 6 months post-surgery 1.2. Complete root coverage (CRC) measured using a clinical assessment of gingival margin position relative to the cementoenamel junction (CEJ) with periodontal probe (PCP-UNC15 HuFriedy), then CRC is calculated as the percentage of sites where full root coverage (no visible root exposure) has been achieved relative to the total number of sites treated, at 6 months post-surgery 2. Recession depth reduction will be assessed through the following measures: 2.1. Gingival thickness measured using a periodontal probe at 6 months post-surgery 2.2. Patient's perception measured using the Patient-Reported Outcome (PRO) Visual Analog Scale (VAS) immediately post-op (within 2-4 hours), Day 1 (24 hours post-surgery), Day 3 (72 hours post-surgery), Day 7 (1 week post-surgery) and at Day 14 and 1 month for delayed pain assessment 2.3 Esthetic outcomes measured using the Root Coverage Esthetic Score (RES) at the final 6-month visit	—

Measure

Time frame

1. Clinical attachment level gain will be assessed through the following measures: 1.1. Probing depth measured using a periodontal probe (PCP-UNC15 HuFriedy ) with a consistent reference point (CEJ) measured to the gingival margin position at 6 months post-surgery 1.2. Complete root coverage (CRC) measured using a clinical assessment of gingival margin position relative to the cementoenamel junction (CEJ) with periodontal probe (PCP-UNC15 HuFriedy), then CRC is calculated as the percentage of sites where full root coverage (no visible root exposure) has been achieved relative to the total number of sites treated, at 6 months post-surgery 2. Recession depth reduction will be assessed through the following measures: 2.1. Gingival thickness measured using a periodontal probe at 6 months post-surgery 2.2. Patient's perception measured using the Patient-Reported Outcome (PRO) Visual Analog Scale (VAS) immediately post-op (within 2-4 hours), Day 1 (24 hours post-surgery), Day 3 (72 hours post-surgery), Day 7 (1 week post-surgery) and at Day 14 and 1 month for delayed pain assessment 2.3 Esthetic outcomes measured using the Root Coverage Esthetic Score (RES) at the final 6-month visit

—

Countries

Romania

Contacts

Public ContactMeizi Eliezer

meizi.eliezer@gmail.com+9720522577260

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026