Changes in aortic blood flow over several years in patients with diseases of the aortic valve measured by cardiac MRI

Longitudinal evaluation of aortic hemodynamics in patients with aortic stenosis and patients with bicuspid aortic valve using 4D flow in cardiovascular magnetic resonance imaging - A follow up investigation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17935517

Enrollment

Registered

2018-08-07

Start date

2011-07-27

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with tricuspid aortic valve or bicuspid aortic valve, with or without stenosis. Circulatory System Tricuspid aortic valve Bicuspid aortic valve Aortic stenosis

Interventions

Two cardiac magnetic resonance examinations were performed per patient to acquire images displaying the aortic flow. Each patient received one examination after inclusion in the study and one 4 to 7 y

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Over 18 years of age 2. Written consent 3. Known aortic stenosis and/or bicuspid aortic valve

Exclusion criteria

Exclusion criteria: 1. Claustrophobia 2. Contraindications to CMR, including implants or metallic objects 3. Pregnant

Design outcomes

Primary

Measure	Time frame
Images of the aorta and aortic flow were acquired using 4D flow MRI at the beginning of the study and 4-7 years following this. These images were analysed for the following and the results from each time point compared: 1. Flow patterns 2. Volumes 3. Wall shear stress	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026