Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
After enrollment in the study, both MS and healthy participants go through two types of cognitive assessment in a randomized order. Participants take the recently developed integrated cognitive assess
Sponsors
Cognetivity Ltd
Royan Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Definite diagnosis of MS in all the following categories, regardless of age, sex and education level: 1.1. RR: relapsing remitting 1.2. PP: primary progressive 1.3. SP: secondary progressive 2. Healthy controls within an age-range similar to the MS patients
Exclusion criteria
Exclusion criteria: 1. Moderate to Severe Depression as measured by Beck’s Score 2. Interfering motor problems (e.g. upper limb motor dysfunction) 3. Vision problems that cannot be corrected with eye-glasses such that it prevents participant from reading 4. Presence of other neurological disorders medical illnesses that affect brain function and cognition 5. History of seizures 6. History of drug or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Cognitive dysfunction is measured using the BICAMS score at baseline, and four months 2. Cognitive dysfunction is measured using the Integrated Congitive Assessmnet (ICA) score at baseline and four months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reliability for SDMT is measured by correlating SDMT categorizations (i.e. cognitively intact, mildly impaired, severely impaired) made on the first visit and the second visit 2. Reliability for ICA is measured by correlating ICA categorizations (i.e. cognitively intact, mildly impaired, severely impaired) made on the first visit and the second visit | — |
Countries
Iran
Outcome results
None listed