Investigating tranexamic acid for bleeding control in facelift surgery

Effects of local tranexamic acid on bleeding during rhytidectomy and post operative complication: randomized, controlled, single-blind trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17892023

Enrollment

Registered

2025-11-06

Start date

2024-05-01

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of bleeding and postoperative complication in Rhytidectomy Surgery

Interventions

Control: Tumescent ( 0.5% lidocaine with 1:200,000 epinephrine). Case: Tranexamic acid (TXA) +Tumescent ( 1 mg/ml TXA and 0.5% lidocaine with 1:200,000 epinephrine) Administration Rout: Local Infiltr

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. = 35-year-old 2. Capable for follow up 3. Healthy patients or with compensated comorbidities, after the agreement of the assigned health care team 4. Candidates for cosmetic face and neck surgery 5. Absence of previous surgeries on the face

Exclusion criteria

Exclusion criteria: 1. < 35-year-old 2. History of thromboembolic events or seizure 3. History of bleeding disorder 4. Active use of oral contraceptive pills and/or hormone replacement therapy, Aspirin, anti-coagulant, and Omega 3 5. Patient preference 6. Any condition increase edema (Renal failure, heart failure, liver disease)

Design outcomes

Primary

Measure	Time frame
Certainly, Nicholas. Here's the revised list of outcome measures in the correct format: 1. Intraoperative blood loss is measured using the volume collected in the surgical suction container during surgery 2. Intraoperative blood loss is measured using gravimetric analysis by weighing surgical sponges and gauze before and after use during surgery 3. Postoperative edema is measured using a subjective 3-point scale (mild, moderate, severe) assessed by both patient and surgeon at postoperative visits 1, 6, and 9 4. Postoperative ecchymosis is measured using a subjective 3-point scale (mild, moderate, severe) assessed by both patient and surgeon at postoperative visits 1, 6, and 9 5. Postoperative edema is measured using objective volumetric assessment with Vectra imaging at postoperative visits 1, 6, and 9 6. Postoperative ecchymosis is measured using objective volumetric assessment with Vectra imaging at postoperative visits 1, 6, and 9	—

Measure

Time frame

Certainly, Nicholas. Here's the revised list of outcome measures in the correct format: 1. Intraoperative blood loss is measured using the volume collected in the surgical suction container during surgery 2. Intraoperative blood loss is measured using gravimetric analysis by weighing surgical sponges and gauze before and after use during surgery 3. Postoperative edema is measured using a subjective 3-point scale (mild, moderate, severe) assessed by both patient and surgeon at postoperative visits 1, 6, and 9 4. Postoperative ecchymosis is measured using a subjective 3-point scale (mild, moderate, severe) assessed by both patient and surgeon at postoperative visits 1, 6, and 9 5. Postoperative edema is measured using objective volumetric assessment with Vectra imaging at postoperative visits 1, 6, and 9 6. Postoperative ecchymosis is measured using objective volumetric assessment with Vectra imaging at postoperative visits 1, 6, and 9

—

Secondary

Measure	Time frame
1. Patient satisfaction is measured using the FACE-Q questionnaire at baseline (before procedure) and postoperative day 9 2. Time to drain removal is measured using clinical records at end of study 3. Complications will be assessed at follow up visits: - Skin necrosis - Hematoma - Thromboembolic events - Infection	—

Countries

Saudi Arabia

Contacts

Public ContactAbdulaziz Alderaywsh

aalderaywsh@ksu.edu.sa-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026