Cerebral oxygenation during changes in vascular resistance and flow in patients on cardiopulmonary bypass

Cerebral oxygenation during changes in vascular resistance and flow in patients on cardiopulmonary bypass: a randomized cross over trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17891643

Enrollment

Registered

2015-10-22

Start date

2010-03-23

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physiology of brain perfusion. Nervous System Diseases

Interventions

During the cardiopulmonary bypass-phase of cardiac operations, when the patients were hemodynamically stable and a CPB-flow was 2.6 L•m-2•min-1 subjects underwent three interventions in randomized ord

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years 2. Patients scheduled for elective cardiac surgery (CABG, aortic valve repair, mitral valve repair or combinations of the former), using mil hypothermic cardiopulmonary bypass. 3. Written informed consent present

Exclusion criteria

Exclusion criteria: 1. Age =18 years 2. Emergency operations 3. Brain pathology in history (CVA) 4. Severe carotid artery stenosis (if no data is available, an echo-Doppler will be performed by the anesthesiologist after induction of anesthesia, prior to surgery) 5. Severe COPD 6. Absent informed consent 7. SaO2<90% at room temperature 8. Diabetes 9. Kidney failure

Design outcomes

Primary

Measure	Time frame
Cerebral oxygenation before and after each intervention.	—

Secondary

Measure	Time frame
Arterial blood pressure before and after each intervention.	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026