Periostin and periodontal disease as modifiers of atherosclerotic coronary artery disease

Periostin and periodontal disease as modifiers of atherosclerotic coronary artery disease: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17884414

Enrollment

Registered

2015-11-23

Start date

2016-02-01

Completion date

Unknown

Last updated

2018-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal and atherosclerotic coronary artery disease Circulatory System Atherosclerotic cardiovascular disease

Interventions

1. Intervention: surgical treatment of periodontal disease by periodontal pocket reduction (modified Widman flap) and bone surgery (to smooth shallow boney craters) if required. 2. Control: no treatme

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 2. Diagnosed atherosclerotic coronary artery disease 3. Diagnosed chronic severe periodontal disease

Exclusion criteria

Exclusion criteria: 1. Coronary event less than 6 months before enrolment 2. Renal failure (creatinine>1.5mg/dL) 3. Uncontrolled liver or pulmonary disease 4. Malignant tumour 5. Autoimmune disease 6. Neurologic or psychiatric disorder 7. Uncontrolled diabetes mellitus (HbA1c >8) 8. Presence of infectious disease (aside from periodontal) 9. Antibiotic or periodontal therapy 3 months before start of study 10. Alcoholism or drug abuse 11. Total edentulism 12. Other ongoing oral condition (orthodontic treatment, caries, etc.) 13. Any other contraindication for treatment or unwilling or unable for any reason to provide informed consent and participate in study. Exclusion criteria after enrolment: 1. Periodontal disease progression of more than 2mm at the 3 months re-evaluation, (re)infarction, cardiovascular (re)intervention, or death.

Design outcomes

Primary

Measure	Time frame
Serum markers of atherosclerotic coronary artery disease and periostin.	—

Secondary

Measure	Time frame
Associated signs and markers of atherosclerosis and periodontal status.	—

Countries

Spain

Contacts

Public ContactMiguel Padial-Molina

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026