Effects of anaesthesia and oxytocin on maternal vascular tone

Effects of oxytocin and anaesthesia on vascular tone in pregnant women: a randomised double-blind placebo-controlled study using non-invasive pulse wave analysis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17860978

Enrollment

Registered

2018-05-16

Start date

2013-01-01

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular tone and hemodynamic change in pregnancy Pregnancy and Childbirth

Interventions

Participants are randomised by a web-based random number generator to a treatment or placebo group. Those in the treatment group receive 8.3 µg (5 U) Oxytocin by injection during the first trimester s

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women 2. Aged 18 years and over 3. Scheduled for termination of pregnancy in the first trimester by vacuum aspiration or curettage

Exclusion criteria

Exclusion criteria: 1.Gestational age above 12 weeks in viable pregnancies 2. Age less than 18 years 3. Do not understand Swedish 4. Serious cardiovascular disorders.

Design outcomes

Primary

Measure	Time frame
The effect of oxytocin on vascular tone and cardiac LV ejection fraction is assessed using digital photoplethysmography pulse wave analysis (DPA) variables before and 1 minute after each injection.	—

Secondary

Measure	Time frame
The effect of anaesthesia on vascular tone and cardiac LV ejection fraction is assessed by digital photoplethysmography pulse wave analysis (DPA) variables before and after induction of anaesthesia.	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 23, 2026