Urge incontinence, detrusor hyperreflexia with impaired contractility (DHIC) Urological and Genital Diseases Urge incontinence
Conditions
Interventions
1. Immediate release oxybutynin following treatment of reversible causes, dose titrated for four weeks and maintained for further four weeks
2. Control group: placebo
Sponsors
National Institutes of Health (USA)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Cognitively intact, community-dwelling persons at least 55 years old with urge incontinence at least every two days
Exclusion criteria
Exclusion criteria: 1. Significant stress incontinence 2. Outlet obstruction 3. Post-voiding residual (PVR) urine >300 ml 4. Mini mental state examination (MMSE) <24/30 5. Inability to go to the toilet independently 6. Contraindication to antimuscarinic therapy 7. Gastrointestinal obstruction 8. Megacolon 9. Severe liver or renal disease 10. Uncontrolled hyperthyroidism 11. Multiple sclerosis 12. Anteroposterior resection 13. Pelvic radiation 14. Spinal cord disease resulting in para- or quadri-plegia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage reduction in incontinence episodes on 4-day bladder diary | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of subjects dry at end of study 2. Subjective satisfaction | — |
Countries
United States of America
Outcome results
None listed