Oxygen treatment using high flow nasal oxygen after major abdominal surgery

High flow nasal oxygen for patients undergoing elective major abdominal surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17843119

Enrollment

200

Registered

2025-12-03

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult patients undergoing elective major abdominal surgery Surgery

Interventions

The master protocol for this study is registered at https://www.isrctn.com/ISRCTN14639555 Eligible patients will be approached for consent before surgery. If consented their baseline and demographic

Eligibility

Sex/Gender

All

Age

50 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 50 years and over undergoing elective major abdominal surgery, using open, laparoscopic or robotic surgical technique

Exclusion criteria

Exclusion criteria: 1. Inability or refusal to provide informed consent 2. Anticipated requirement for invasive or non-invasive respiratory support for at least 4 hours after surgery as part of routine clinical care 3. Previous enrolment in the PROTECT-HFNO comparison 4. Clinician refusal

Design outcomes

Primary

Measure	Time frame
Patient outcome measures: 1.Postoperative pulmonary complications within 30 days after surgery, a composite outcome comprising: pneumonia, Acute Respiratory Distress Syndrome and/or Pulmonary Aspiration. 2.Re-intubation within 30 days after surgery. 3.DAH30 4.All complications graded by Clavien-Dindo within 30 days of surgery 5.Mortality within 30 days of surgery 6.Duration of hospital stay (number of days from day or surgery until hospital discharge) within 30 days after surgery 7.Compliance with HFNO, including duration delivered and any reasons for discontinuation 8.Adverse events associated within HFNO within 12 hours from end of surgery Hospital level outcome measures: 1.Number of eligible patients per year in each hospital 2.Number of patients consented per year in each hospital 3.Included hospital randomising at least one patient within the 12-month recruitment period 4.Number of consultant surgeons and anaesthetists in each hospital who support recruitment of the patients in their care in principle as a proportion of those delivering care for elective major abdominal surgery 5.Number of consultant surgeons and anaesthetists in each hospital who do not support recruitment of the patients in their care in principle as a proportion of those delivering care for elective major abdominal surgery	—

Measure

Time frame

Patient outcome measures: 1.Postoperative pulmonary complications within 30 days after surgery, a composite outcome comprising: pneumonia, Acute Respiratory Distress Syndrome and/or Pulmonary Aspiration. 2.Re-intubation within 30 days after surgery. 3.DAH30 4.All complications graded by Clavien-Dindo within 30 days of surgery 5.Mortality within 30 days of surgery 6.Duration of hospital stay (number of days from day or surgery until hospital discharge) within 30 days after surgery 7.Compliance with HFNO, including duration delivered and any reasons for discontinuation 8.Adverse events associated within HFNO within 12 hours from end of surgery Hospital level outcome measures: 1.Number of eligible patients per year in each hospital 2.Number of patients consented per year in each hospital 3.Included hospital randomising at least one patient within the 12-month recruitment period 4.Number of consultant surgeons and anaesthetists in each hospital who support recruitment of the patients in their care in principle as a proportion of those delivering care for elective major abdominal surgery 5.Number of consultant surgeons and anaesthetists in each hospital who do not support recruitment of the patients in their care in principle as a proportion of those delivering care for elective major abdominal surgery

—

Secondary

Measure	Time frame
There are no secondary outcome measures as this is a feasibility study	—

Countries

England, United Kingdom

Contacts

Public ContactBecky Dodds

Protect-admin@qmul.ac.uk+44 (0)203 594 0349

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026