Intensive care unit acquired weakness Musculoskeletal Diseases Muscle wasting and atrophy, not elsewhere classified
Conditions
Interventions
The skeletal muscle of survivors of critical illness will be studied using 3 broad approaches:
1. Magnetic resonance imaging (MRI)
2. 2D ultrasound imaging
3. Clinical assessment (quadricpes dynamome
Medical Research Council sum-score of global muscle strength
6 minute walk test)
4. Blood samples will be drawn for serological analysis
Sponsors
University of Edinburgh
NHS Lothian
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Group 1 (10 patients): 1. Adult ICU survivors 2. Ventilated for 48 hours or more 3. Good level of physical function prior to hospital admission (Rivermead Mobility Index (RMI) >/14 at any time in the week prior to hospital admission) 4. Within 7 days of ICU discharge 5. Evidence of very poor physical recovery (RMI =8) Group 2 (10 patients): 1. Adult ICU survivors 2. Paired by age, gender and body mass index (BMI) to Group 1 3. Ventilated for 48 hours or more 4. Good level of physical function prior to hospital admission (RMI =15 at any time in the week prior to hospital admission) 5. Within 7 days of ICU discharge 6. Evidence of very good physical recovery (RMI = 9) Group 3 (10 patients): 1. A healthy community based sample derived from patients presenting for day case surgery. 2. Paired by age, gender, and BMI to groups 1 and 2 3. Good level of physical function (RMI = 15)
Exclusion criteria
Exclusion criteria: Exclusion criteria for groups 1 and 2: 1. <18 years of age 2. Patient receiving palliative care 3. Patient has a contraindication to MRI imaging 4. Neurological diagnosis 5. Background chronic neuromuscular disease 6. Patient lacks mental capacity 7. Malignancy 8. Chronic inflammatory disease 9. Clinical instability Exclusion criteria for group 3 1. <18 years 2. Malignancy 3. Chronic inflammatory disease 4. Background chronic neuromuscular disease 5. Neurological diagnosis 6. Presenting for lower limb arthroplasty 7. Patient lacks mental capacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For group 1 all measurements will be taken at baseline and 3 months; for groups 2 and 3 all measurements will be taken at baseline only: 1. Quadriceps muscle volume. | — |
Secondary
| Measure | Time frame |
|---|---|
| For group 1 all measurements will be taken at baseline and 3 months; for groups 2 and 3 all measurements will be taken at baseline only: 1. Qualitative assessment of muscle oedema and focal inflammation 2. Relative fat fraction (measured by the three-point Dixon method) 3. Mean elasticity (measured in KPa using magnetic resonance elastography) 4. Quadriceps strength (quadriceps dynamometry) | — |
Countries
United Kingdom
Contacts
Public ContactDawn Campbell
Outcome results
None listed