Does S(+)-ketamine or the combination of S(+)-ketamine and magnesium reduce post-operative opioid requirements after abdominal surgery?

Does S(+)-ketamine or the combination of S(+)-ketamine and magnesium reduce post-operative opioid requirements after abdominal surgery? A prospective double blinded randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17811636

Enrollment

Registered

2011-04-28

Start date

2004-03-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective open abdominal surgery Surgery Abdominal surgery

Interventions

Anaesthesia was given in a standardised way

premedication was given using midazolam 3.75 mg orally. Induction using propofol 2 mg/kg, rocuronium 0.6 mg/kg and remifentanyl 0.1 - 1 µg/kg/min by continuous infusion. For maintenance of anaesthesi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with category I and II American Society of Anesthesiologists (ASA) classification 2. Aged between 18 to 70 years old, either sex

Exclusion criteria

Exclusion criteria: 1. Extensive previous use of pain therapy 2. Previous strong side-effects caused by ketamine 3. Alcohol abuse 4. Use of psychotropics 5. Severe mental disease 6. Reintervention laparotomy due to complications

Design outcomes

Primary

Measure	Time frame
Total amount of piritramide used at 48 hours	—

Secondary

Measure	Time frame
1. Piritramide use at 12 and 24 hours 2. VAS pain scores at 0.5, 1, 2, 3, 4, 8, 12, 24 and 48 hours 3. Vital parameters 4. Incidence of side-effects	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026