Acute exacerbations of chronic obstructive pulmonary disease (COPD) patients with mild respiratory acidosis Respiratory Chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
Comparison of two groups of COPD:
1. A standard goup: COPD patients with standard treatment alone
2. An IPV group: COPD patients with standard treatment plus IPV
Sponsors
Pellegrin-Tripode Hospital (France)
Eligibility
Inclusion criteria
Inclusion criteria: COPD patients in acute excerbations and respiratory acidosis with pH between 7.35 and 7.38
Exclusion criteria
Exclusion criteria: 1. The requirement for emergency intubation for cardiopulmonary resuscitation, respiratory arrest, or in the case of rapid deterioration in neurological status (Glasgow coma scale inferior or equal to 8) 2. Hemodynamic instability defined as a systolic blood pressure of less than 80 mmHg or evidence on electrocardiography of ischemia or clinically significant ventricular arrhythmias 3. Failure of more than two additional organs; or tracheotomy, pneumothorax, facial deformity, or a recent history of oral, oesophageal or gastric surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Therapy was considered to be successful when it enabled the avoidance of both a worsening of the exacerbation and a decrease in pH to under 7.35 (which would have required NIV), and allowed the patient to be discharged from the ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
France
Outcome results
None listed