Anti-aging Skin and Connective Tissue Diseases
Conditions
Interventions
This study is a single-arm clinical trial comprising a 2-week washout period followed by an 8-week treatment phase. During the washout phase, eligible participants were permitted to use one set of sta
the product was kept away the eyes. No other skin care or facial makeup products were permitted except for lip and eyebrow makeup during the entire study period. Follow-up visits were scheduled at fiv
Sponsors
L’oreal China Research and Innovation Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Chinese women, 20–45 years old 2. All skin types 3. Usually have rich expression, love to laugh, often raise eyebrows and frown 4. Presenting obvious dynamic lines while making following facial expression adjusted by Dermatologist: 4.1. Smile expression: 4.1.1. Underneath eye wrinkles: 3 < grade = 9 (L'Oréal Atlas Page 46–47) 4.1.2. Crow's feet wrinkle: 3 < grade = 6 (L'Oréal Atlas Page 40–41) 4.1.3. Nasolabial folds: 1 < grade = 7 (L'Oréal Atlas Page 54–55) 4.2. Raise eyebrow expression: 4.2.1. Forehead wrinkles: 3 < grade = 8 (L'Oréal Atlas Page 32–33) 4.3. Frown expression: 4.3.1. Glabellar wrinkles: 2 < grade = 6 (L'Oréal Atlas Page 36–37) 5. Did not participate in any clinical test or cosmetic product test on skin within 3 months 6. No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer 7. In general, good health at the time of the study 8. Willing and able to participate as evidenced by signing of informed consent and photo release 9. Must be willing to comply with all study protocol requirements
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding woman or woman planning pregnancy during the study 2. Subject deprived of rights by a court or administrative order 3. Major subject to a guardianship order 4. Subject residing in a health or social care establishment 5. Patient in an emergency setting 6. Volunteer with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema) 7. Volunteer presenting a stable or progressive serious disease (per investigator's assessment) 8. Immuno-compromised subject 9. Subject with history of allergy to cosmetic or personal care products or ingredients 10. Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment) 11. Subjects regularly practicing aquatic or nautical sports 12. Subjects regularly attending a sauna
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Static lines are measured using the Skin Aging Atlas (Flament 2010) at baseline, Timm (15 minutes after product application), and at weeks 3, 4, and 8 2. Skin firmness is measured using the 10-point Griffiths scale at baseline, Timm, and at weeks 3, 4, and 8 3. Skin elasticity is measured using the 10-point Griffiths scale at baseline, Timm, and at weeks 3, 4, and 8 4. Global fine lines are measured using the 10-point Griffiths scale at baseline, Timm, and at weeks 3, 4, and 8 5. Dynamic wrinkles are measured using photographic grading with the Skin Aging Atlas at Timm, and at weeks 4 and 8 6. Gross elasticity (R5) is measured using the Cutometer Dual Skin Elasticity Meter MPA580 at Timm, and at weeks 4 and 8 7. Net elasticity (R2) is measured using the Cutometer Dual Skin Elasticity Meter MPA580 at Timm, and at weeks 4 and 8 8. Biological elasticity (R7) is measured using the Cutometer Dual Skin Elasticity Meter MPA580 at Timm, and at weeks 4 and 8 9. Participant self-assessed outcomes are measured using self-assessment questionnaires at baseline, Timm, and at weeks 3, 4, and 8 10. Safety is assessed at week 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
China
Contacts
Public ContactJing Li
Outcome results
None listed