Ventricular fibrillation Circulatory System Ventricular fibrillation
Conditions
Interventions
Participants are recruited at the point of first STEMI. Baseline demographics and previous medical history are collected by researchers by using standardized questionnaires while the participant is in
Sponsors
University Hospital of Copenhagen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cases 1. First STEMI patients who experienced VF within the first 12 hours of symptoms of STEMI before PPCI 2. Age between 18 and 80 years 3. Caucasians 4. Cardiac symptoms lasting =12 hours 5. Acute ST-segment elevation revealed by ECG Controls: 1. First STEMI patients who did not have VF during the first 12 hours of symptoms of STEMI before PPCI 2. Age between 18 and 80 years 3. Caucasians 4. Cardiac symptoms lasting =12 hours 5. Acute ST-segment elevation revealed by ECG
Exclusion criteria
Exclusion criteria: 1. Cases and controls who developed VF during PPCI will be excluded because VF during PPCI is believed to be reperfusion induced; however, case patients with VF before PPCI who continued to have VF during PPCI can participate 2. Other exclusions included VF after PPCI 3. Congenital heart defects 4. Known structural heart disease 5. Use of class I and III antiarrhythmic drugs 6. Recent cancer 7. Major surgery or trauma within 4 weeks 8. Presentation with potassium concentration of 5 mmol/L 9. Because we also planned to identify genetic markers associated with VF, and because >90% of the Danish populations are white Danes, we excluded non-white Danes to reduce the risk of population stratification for future genetic analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Common and rare genetic variants associated with ventricular fibrillation (VF) during first ST-elevation myocardial infarction (STEMI), analysed by genome-wide association studies and next generation sequencing | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality is measured using the Danish registries continuously for 5 years | — |
Countries
Denmark
Outcome results
None listed