Diversity in blood flow control to the brain

Diversity in blood flow control to the brain: moving from individualized modelling towards personalized treatment of the injured brain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17736632

Enrollment

Registered

2014-05-09

Start date

2014-09-29

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute and chronic stroke Circulatory System Stroke, not specified as haemorrhage or infarction

Interventions

Initial assessments will be undertaken in a dedicated cardiovascular research laboratory, which is at a controlled temperature (20-24 degrees celsius) and is free from distraction. Beat-to-beat blood

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participant (or relative of the stroke patient) is willing and able to give informed consent (assent) for participation in the study 2. Male or female, aged 18 years or above 3. Able (in the investigator's opinion) and willing to comply with all study requirements 4. Willing to allow his or her General Practitioner to be notified of participation in the study Stroke patient-specific inclusion criteria: 1. Clinical diagnosis of stroke within 24 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic)

Exclusion criteria

Exclusion criteria: Co-morbidity with life expectancy less than 3 months

Design outcomes

Primary

Measure	Time frame
This is not an intervention study, and therefore it would not be appropriate to assess the classical primary and secondary outcome measures such as death and disability for this study. However, we intend to evaluate the following relevant outcomes: 1. The percentage of recruited subjects (acute stroke patients and healthy volunteers) able to comply with the full measurement protocol 2. The percentage of measurements rejected because of aspects related to data quality during the analysis protocol, with recorded reasons 3. Overall, the percentage of recruited subjects (acute stroke patients and healthy volunteers) in whom values for the following parameters can be derived: 3.1. Autoregulation index (using the Tiecks model and from the phase, gain and coherence) 3.2. Baroreceptor Sensitivity index (using power spectral analysis to acquire the á index) 3.3. % change in coronary blood flow velocity at baseline and in response to a hypercapnic and passive motor stimulus 3.4. Indices of dynamic CA, cerebrovascular reactivity and neurovascular coupling	—

Measure

Time frame

This is not an intervention study, and therefore it would not be appropriate to assess the classical primary and secondary outcome measures such as death and disability for this study. However, we intend to evaluate the following relevant outcomes: 1. The percentage of recruited subjects (acute stroke patients and healthy volunteers) able to comply with the full measurement protocol 2. The percentage of measurements rejected because of aspects related to data quality during the analysis protocol, with recorded reasons 3. Overall, the percentage of recruited subjects (acute stroke patients and healthy volunteers) in whom values for the following parameters can be derived: 3.1. Autoregulation index (using the Tiecks model and from the phase, gain and coherence) 3.2. Baroreceptor Sensitivity index (using power spectral analysis to acquire the á index) 3.3. % change in coronary blood flow velocity at baseline and in response to a hypercapnic and passive motor stimulus 3.4. Indices of dynamic CA, cerebrovascular reactivity and neurovascular coupling

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026