Exploring how gentle nerve stimulation in the ankle affects the body’s automatic functions in healthy people

Healthy volunteers receiving transcutaneous tibial nerve stimulation to assess acute changes in heart rate variability across baseline, stimulation and post-stimulation phases

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17718049

Enrollment

Registered

2025-12-29

Start date

2024-12-11

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute autonomic nervous system modulation (heart rate variability, HRV) in healthy volunteers during transcutaneous tibial nerve stimulation (TTNS). Other

Interventions

Intervention: Transcutaneous tibial nerve stimulation (TTNS) delivered with a TENS device (TENS 7000®), continuous stimulation for 10 minutes at 30 Hz and 200 µs pulse width. Two self-adhesive surface

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Adults (=18 years) 2. Healthy volunteers without known chronic disease 3. Able to provide written informed consent 4. Comply with the study procedures

Exclusion criteria

Exclusion criteria: 1. Recent surgery within 3 months 2. Current medications affecting autonomic function 3. Any condition preventing safe participation or valid HRV measurement

Countries

Chile

Contacts

Public ContactJavier Muñoz

doctormunozquintana@gmail.com+56 991588386

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 7, 2026