Refractory temporomandibular joint arthralgia associated with degenerative joint disease and unilateral or bilateral disc displacement without reduction Mental and Behavioural Disorders
Conditions
Interventions
Hyaluronic Acid (HA) Injection Group:
Participants in this group receive an injection of 1 ml of hyaluronic acid directly into the jaw joint (temporomandibular joint - TMJ). This treatment is believed
Sponsors
Facultad odontologia Universidad de Granada
Serviços Assistência Médico Social - Sindicato dos Bancários Sul e Ilhas
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 27/07/2026: 1. Adults aged 18–70 years 2. Diagnosis of temporomandibular joint arthralgia, degenerative joint disease and disc displacement without reduction according to the Diagnostic Criteria for Temporomandibular Disorders 3. Symptoms present for at least 6 months 4. Persistent pain, defined as a Visual Analogue Scale score of at least 5, and functional limitation despite at least 3 months of previous conservative management 5. Degenerative joint disease confirmed by cone-beam computed tomography and disc displacement without reduction confirmed by magnetic resonance imaging Previous inclusion criteria: 1. Both sexes 2. 18 to 70 years of age 3. Previous history of TMJ blocking 4. Acute or chronic temporomandibular disorder (TMD) uni- or bi-lateral
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 27/07/2026: 1. Previous temporomandibular joint surgery, intra-articular injection, fracture or ankylosis 2. Exclusively muscular temporomandibular disorder 3. Concurrent treatment for articular temporomandibular disorder 4. Systemic inflammatory joint disease 5. Fibromyalgia 6. Active maxillofacial infection 7. Pregnancy or lactation 8. Severe psychiatric, cognitive, communication or other health conditions likely to interfere with understanding the study, completing questionnaires or following study instructions Previous exclusion criteria: 1. Exclusively muscular TMD 2. Clinical history of TMJ fracture, ankylosis or surgery 3. Patients undergoing other kind of treatment for articular TMD 4. Fibromialgia 5. Pregnancy 6. Patients who are blind, illiterate, or have reduced cognitive abilities that may interfere with communication, understanding of the study, response to questionnaires, or execution of instructions. 7. Known psychiatric or physical comorbidities that may interfere with communication or execution of instructions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Chronic pain Intensity value according to the Graded Chronic Pain Scale at baseline, 1 month and 12 months 2. Mandibular range of motion according to the DC/TMD measures of pain free opening and maximum unassisted opening at baseline, 1 month and 12 months 3. DC/TMD diagnosis change using the DC/TMD classification system at baseline, 1 month and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quality of life using the OHIP14 questionnaire at baseline, 1 month and 12 months 2. Jaw Functional Limitation using the Jaw functional limitation scale and the disability points according to the Graded Chronic Pain Scale at baseline, 1 month and 12 months 3. Overall TMJ pain assessment with the visual analogue score (VAS) at baseline, 1 month and 12 months after treatment 4. Overall Muscle pain assessment with the visual analogue score (VAS) at baseline, 1 month and 12 months after treatment | — |
Countries
Portugal
Contacts
Public ContactAndre AlmeIda
Outcome results
None listed