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Effects of Maitland’s Mobilization on modulating biomarkers in knee osteoarthritis

Effects of Maitland’s Mobilization on modulating biomarkers in knee osteoarthritis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN17691569
Enrollment
68
Registered
2019-09-16
Start date
2018-07-02
Completion date
Unknown
Last updated
2019-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis Musculoskeletal Diseases Gonarthrosis [arthrosis of knee]

Interventions

Patients will be randomly allocated into two groups by coin tossing method i.e. Maitland’s Mobilization and Conventional Group. Maitland’s Mobilization Protocol may va
however, general treatment protocol is being applied as follows: 1. Frequency of exercise is three days a week on alternative day basis 2. Intensity is Grade I and II b

Sponsors

Higher Education Commission
Lead Sponsor
Riphah International University
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients of either gender 2. Age 50 to 70 years 3. Patients falling in American College of Rheumatology criteria for primary osteoarthritis 4. Patients with chronic pain from last three months 5. Kellgren-Lawrence Classification System for knee osteoarthritis 6. Patients with body mass index not below than 19 kg/m2 and more than 28 kg/m2 7. Patients who have signed informed consent to be willing to participate in study

Exclusion criteria

Exclusion criteria: 1. Patients with trauma in last 6 months 2. Patients with uncontrolled diabetes mellitus and hypertensive disease 3. Associated inflammatory joint disease such as septic arthritis and R.A 4. Patients taking cover of oral or intra-articular Hyaluronic acid 5. Patient on cover of alendronate and/ or sulfonate compounds of sodium 6. Women receiving any treatment that can interfere with bone metabolism such as hormonal replacement therapy after menopause 7. Patients with undiagnosed pathology or impairment, recent surgery, mixed arthritis condition, patients with spinal problems

Design outcomes

Primary

MeasureTime frame
Measured at baseline and every sixth week of treatment: 1. Biomarkers of osteoarthritis measured using ELISA 2. Function, range and pain experienced due to osteoarthritis measured using the Western Ontario and McMaster Universities Arthritis Index (WOMAC)

Secondary

MeasureTime frame
Measured at baseline and every sixth week of treatment: 1. Pain intensity measured using the Numeric Rating Pain Scale 2. Quality of life and problems specific to knee region measured using the Knee Injury and Osteoarthritis Outcome Score (KOOS) 3. General quality of life measured using the SF 36 Short Form

Countries

Pakistan

Contacts

Public ContactMaryam Shabbir

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026