Knee osteoarthritis Musculoskeletal Diseases Gonarthrosis [arthrosis of knee]
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either gender 2. Age 50 to 70 years 3. Patients falling in American College of Rheumatology criteria for primary osteoarthritis 4. Patients with chronic pain from last three months 5. Kellgren-Lawrence Classification System for knee osteoarthritis 6. Patients with body mass index not below than 19 kg/m2 and more than 28 kg/m2 7. Patients who have signed informed consent to be willing to participate in study
Exclusion criteria
Exclusion criteria: 1. Patients with trauma in last 6 months 2. Patients with uncontrolled diabetes mellitus and hypertensive disease 3. Associated inflammatory joint disease such as septic arthritis and R.A 4. Patients taking cover of oral or intra-articular Hyaluronic acid 5. Patient on cover of alendronate and/ or sulfonate compounds of sodium 6. Women receiving any treatment that can interfere with bone metabolism such as hormonal replacement therapy after menopause 7. Patients with undiagnosed pathology or impairment, recent surgery, mixed arthritis condition, patients with spinal problems
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured at baseline and every sixth week of treatment: 1. Biomarkers of osteoarthritis measured using ELISA 2. Function, range and pain experienced due to osteoarthritis measured using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at baseline and every sixth week of treatment: 1. Pain intensity measured using the Numeric Rating Pain Scale 2. Quality of life and problems specific to knee region measured using the Knee Injury and Osteoarthritis Outcome Score (KOOS) 3. General quality of life measured using the SF 36 Short Form | — |
Countries
Pakistan