Osteoporosis Musculoskeletal Diseases
Conditions
Interventions
A total of 42 participants will be recruited into the study, with 21 premenopausal women (aged 18–40 years) and 21 postmenopausal women (=5 years post-menopause, aged 60 years and older). Each partici
Sponsors
Imperial College London
Eligibility
Sex/Gender
Female
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Premenopausal women aged 18-40 years 2. Postmenopausal women (=5 years post menopause) aged 60 years and older 3. Healthy individuals without chronic diseases or conditions that significantly impact the gut microbiome, metabolism, or bone health (e.g., diabetes, inflammatory bowel disease, etc.) 4. HbA1c <48 mmol/mol 5. Individuals with a BMI between 18.5 and 30 kg/m² (normal weight to overweight)
Exclusion criteria
Exclusion criteria: 1. Non-English speakers 2. Individuals with chronic diseases that affect the gut microbiome, metabolic health or bone metabolism (e.g. type 1 or 2 diabetes, bowel diseases such as Crohn’s disease or irritable bowel syndrome, osteoporosis, etc) 3. HbA1c =48 mmol/mol 4. Individuals with a BMI less than 18.5 kg/m² (underweight) or greater than 30 kg/m² (obesity) 5. Medications and dietary supplements in the last 3 months that would impact trial outcomes: 5.1. Antibiotics 5.2. Proton Pump Inhibitors (PPIs) 5.3. Laxatives & Antidiarrheals 5.4. Immunosuppressants 5.5. Metformin 5.6. Nonsteroidal anti-inflammatory drugs 5.7. Bisphosphonates 5.8. Estrogen and/or progesterone (Hormone replacement therapy (HRT)) 5.9. Denosumab 5.10. Anabolic steroids 5.11. Teriparatide 5.12. Thyroid medication 5.13. Dietary fibre, prebiotic or probiotic supplements 6. Known congenital or acquired bone disease other than osteopenia (including osteomalacia, hyperparathyroidism, Paget’s disease) 7. History of major psychiatric illness 8. Drink more than 14 units of alcohol per week on a regular basis 9. Consumption of recreational drugs 10. Current smokers (daily) 11. Pregnancy 12. Not involved in other research projects in the previous 12 weeks
Countries
England, United Kingdom
Contacts
Public ContactEdward Chambers
Outcome results
None listed