Patients with acute respiratory failure requiring invasive mechanical ventilation Respiratory Acute respiratory failure
Conditions
Interventions
After the candidates or their family members sign the informed consent, the research staff contacts the liaison of the lead center for central randomization by specially assigned staff.
painful movements of the body may be slow, cautious movement, touching the pain, and seeking attention through movement.
For patients with internal jugular vein catheterization, if the
Sponsors
Sir Run Run Shaw Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with acute respiratory failure requiring invasive mechanical ventilation *Incorporated within 48 hours after the establishment of the artificial airway 2. Estimated mechanical ventilation time >72 hours 3. Aged over 18 years old
Exclusion criteria
Exclusion criteria: 1. Pneumothorax or mediastinal emphysema 2. Acute myocarditis, severe arrhythmia 3. Neuromuscular diseases that may affect weaning, including myasthenia gravis, motor neuron disease, and congenital myopathy 4. Hemodynamic instability (mean arterial pressure 0.2 ug/kg/min) 5. Paroxysmal sympathetic hyperactivity syndrome 6. Even chest 7. Pregnancy 8. Fitted with a pacemaker/implantable defibrillator 9. Applying neuromuscular blockers (NMBAs) within the past 6 hours 10. History of neck radiation therapy or neck surgery 11. Cancer of the neck and lung 12. Unable to obtain accurate diaphragm ultrasound results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Enrollment rate: number of enrolled patients divided by total number of patients meeting the criteria of this study at 48 hours after the establishment of an artificial airway 2.Retention rate (incorporating acceptability of the therapy): number of patients who completed the study divided by number of patients admitted at the end of the entire experiment 3. Response rate: diaphragmatic mobility measured by ultrasound at the first EDP treatment 4. Incidence rate of adverse events measured using number of patients with adverse events divided by patients enrolled in the group during the entire test | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Diaphragm thickness: at the end of exhalation and inspiration the thickness of the right diaphragm will be measured using diaphragm ultrasound during tidal breathing to calculate the muscle thickening score. Measured at baseline, every other day, for the first SBT (under EDP) and on day 28 2. Diaphragm mobility: right diaphragmatic mobility, inspiratory time, inspiratory slope and acceleration measured using diaphragm ultrasound at the first SBT (under EDP treatment) 3. Duration of mechanical ventilation, reintubation, weaning success rate and survival rate measured using patient records within 28 days 4. Blood gas analysis using blood gas analysis instrument before and after EDP session every morning | — |
Countries
China
Contacts
Public ContactYuejia Ding
Outcome results
None listed