Comparing 3 versus 7 days systemic administration of Amoxicillin (AMX) and Metronidazole (MET) in severe chronic periodontitis patients

A randomized controlled clinical study on non-surgical periodontal treatment in conjunction with 3 versus 7 days systemic administration of Amoxicillin and Metronidazole in severe chronic periodontitis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17605083

Enrollment

102

Registered

2015-06-16

Start date

2012-01-30

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe chronic periodontitis Oral Health Severe chronic periodontitis

Interventions

All patients received oral hygiene instructions and cleanings. Three treatment procedures were performed according to a computer generated randomisation list: - control group: non-surgical periodonta

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. >30 years 2. Diagnosis of severe chronic periodontitis (Armitage 1999) 3. = 12 natural teeth 4. = 1 site/quadrant with pocket depth = 6mm 5. Full-mouth plaque scores = 25% (O`Leary 1972) 6. systemically healthy 7. No allergies for penicillin or 5-nitroimidazole derivates

Exclusion criteria

Exclusion criteria: 1. Non-surgical periodontal therapy within 12 months 2. Systemic/local antibiotics within the previous 3 months 3. Medication that could interact with amoxicilline or metronidazole 4. Pregnancy/lactation

Design outcomes

Primary

Measure	Time frame
Difference of the number of sites per patient with pocket depth = 6 mm between baseline and 6 months	—

Secondary

Measure	Time frame
Secondary variables were changes in: probing pocket depth, clinical attachment level, bleeding on probing, furcation involvement, full-mouth plaque score -FMPS-, gingival bleeding index -GBI, number of sites per patient with PD = 6 mm, number of sites per patient = 5 mm, bacterial load of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tanerella Forsythia, Treponema denticola, Prevotella intermedia, levels of IL-10. IL-1ß, TNF-alpha, MMP-8.	—

Measure

Time frame

Secondary variables were changes in: probing pocket depth, clinical attachment level, bleeding on probing, furcation involvement, full-mouth plaque score -FMPS-, gingival bleeding index -GBI, number of sites per patient with PD = 6 mm, number of sites per patient = 5 mm, bacterial load of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tanerella Forsythia, Treponema denticola, Prevotella intermedia, levels of IL-10. IL-1ß, TNF-alpha, MMP-8.

—

Countries

Romania

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026