Investigating some of the oral manifestations associated with neutropenia - a clinical cross-sectional study

Are patients undergoing chemotherapy who develop chemotherapy-induced neutropenia at greater risk for having oral lesions and periodontal diseases compared with patients without chemotherapy-induced neutropenia?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17585958

Enrollment

Registered

2023-09-06

Start date

2021-10-24

Completion date

Unknown

Last updated

2025-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral manifestations associated with neutropenia in patients with hematological malignancies undergoing chemotherapy Oral Health

Interventions

The study sample consists of 50 patients divided into two groups as follows: the first group includes the hematological malignancies patients with chemotherapy-induced neutropenia (25 patients), and t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: First group (patients with chemotherapy-induced neutropenia): 1. Patients diagnosed with hematological malignancy 2. Patients who received at least one cycle of chemotherapy 3. Patients developing neutropenia after chemotherapy, with an absolute neutrophil count (ANC) less than 1.5 x 10^9/L Second group (patients without chemotherapy-induced neutropenia): 1. Patients diagnosed with hematological malignancy 2. The patient has received at least one cycle of chemotherapy 3. The patient does not present with post-chemotherapy neutropenia, and has an ANC greater than 1.5 x 10^9/L

Exclusion criteria

Exclusion criteria: 1. Patients receive radiation therapy as part of their treatment 2. The patient has been diagnosed with oral cancer 3. The patient is diagnosed with a non-hematological malignancy 4. The patient is diagnosed with diabetes

Design outcomes

Primary

Measure	Time frame
1. Oral manifestations measured using clinical and visual diagnosis at a single timepoint 2. Periodontal diseases measured using clinical and visual diagnosis at a single timepoint 3. Quality of life measured using a questionnaire that concentrates on different aspects of life as a result of neutropenia/chemotherapy at a single timepoint	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Syria

Contacts

Public ContactFatima Alzahraa Al Beesh

fatimaalzahraa.albeesh@damascusuniversity.edu.sy+963994621887

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026