Early stage glottic cancer Cancer Head and neck cancer
Conditions
Interventions
Endoscopic excision or standard radiotherapy
Sponsors
University College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed squamous cell carcinoma of the glottic larynx, including tumours at the anterior commisure 2. Stage Tis, T1, T2a, N0, M0 3. Anatomy of airways suitable for endoscopic excision 4. Fit to receive radical treatment as either radiotherapy or endoscopic excision 5. Age 18 years or greater 6. Willing to participate in a recruitment appointment 7. Willing to complete voice and quality of life questionnaires 8. Available for follow up within the UK
Exclusion criteria
Exclusion criteria: 1. Any clinical or radiological sign of nodal involvement 2. Any evidence of clinical metastases 3. Any previous cancer within 10 years (except basal cell carcinoma of the skin and adequately treated carcinoma-in-situ of the uterine cervix) 4. Concomitant chemotherapy 5. Patients with vasculitic conditions adversely affecting radiotherapy 6. Pregnancy 7. Other co-existing medical condition such that life expectancy is less than two years 8. Treatment with palliative intent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed