Pre-hypertension Circulatory System Pre-hypertension
Conditions
Interventions
As this is a crossover study with treatment assessed within volunteer, stratification of allocation to treatment sequences will be done within gender only, and also by sequence of joining the study (t
Sponsors
University of Aberdeen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women 2. Aged 30-65 years 3. Body mass index (BMI) between 18.5 and 35kg/m2 4. 135mmHg<SystolicBP<159 mm Hg and/or 85 mm Hg<DiastolicBP<99 mm Hg
Exclusion criteria
Exclusion criteria: 1. 160 mm Hg 7.0mmol/L, asthma, or thyroid conditions 3. Subjects with eating disorders, high habitual intake of wholegrain food (> 7 portions per weeks) or taking regular medication or supplements known to affect any dependant variable measured 4. Pregnant women 5. Individuals with bowel disorders (Crohn’s, IBS, coeliac)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure is measured using blood pressure cuffs and 24hr ABPM at six weeks follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Arterial stiffness (Aix) and central aortic pressure is measured using Sphygomocor at six weeks follow up 2. Diastolic blood pressure is measured using blood pressure cuffs and 24hr ABPM at six weeks follow up 3. Aldosterone and angiotensin concentration in plasma measured using blood tests at six weeks follow up 4. Kidney function is determined using estimated glomerular filtration rate (eGFR) based on serum creatinine concentration at six weeks follow up | — |
Countries
United Kingdom
Outcome results
None listed