Gestational diabetes: hyperglycaemia that is first recognised in pregnancy Pregnancy and Childbirth Diabetes mellitus arising in pregnancy
Conditions
Interventions
Dietary intervention: calorie reduction to 1,200 kcal for four weeks.
Magnetic resonance spectroscopy will be used to quantify liver fat before and after a four-week dietary intervention. A standardis
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Greater than 20 weeks pregnant 3. Gestational diabetes (oral glucose tolerance test greater than/equal to 5.1 mmol/l, or 2-hour glucose greater than/equal to 7.8 mmol/l)
Exclusion criteria
Exclusion criteria: Contraindication to MRI: 1. Pacemaker/ferromagnetic implants 2. Metallic fragments in eye 3. Piercings that cannot be removed 4. Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Liver fat – measured at baseline and after 4 weeks of dietary intervention by magnetic resonance spectroscopy 2. Glycaemic control – measured by home blood glucose monitoring in the first and fourth weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Insulin/C peptide/glucose response to a standardised meal test. Measured at baseline and after 4 weeks of dietary intervention 2. Lipid profile – measured using nuclear magnetic spectroscopy at baseline and 4 weeks of dietary intervention 3. HBA1c – measured at baseline and after 4 weeks of dietary intervention 4. Feasibility and acceptibility of dietary intervention in pregnancy (qualitative study) – assessed by semi-structured interview after the dietary intervention and analysed using the theory domain framework | — |
Countries
United Kingdom
Outcome results
None listed