Osteoarthritis Musculoskeletal Diseases
Conditions
Interventions
This was a randomized controlled trial study for 4 weeks. Subjects were divided into 3 groups randomly:
1. Group I: combination of CB extract (Biocurpain
350 mg of Curcuma longa and 150 mg Boswellia serrata) and NSAID (400 mg of ibuprofen or 50 mg of diclofenac sodium)
2. Group II: CB extract alone
3. Group III: NSAID al
Sponsors
Duta Wacana Christian University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Diagnosed with osteoarthritis of the knee (Kellgren-Lawrence grade II or III) for at least 4 weeks
Exclusion criteria
Exclusion criteria: 1. Not willing to join the study. 2. Subjects with known hypersensitivity to biocurpain ingredients and/or ibuprofen, diclofenac sodium or paracetamol 3. Participation in other clinical trial for the last 1 month 4. Significant renal, hepatic, gastrointestinal, and cardiovascular comorbidities 5. Pregnant or trying to become pregnant 6. Incompetent to give consent and answer the questionnaire 7. Received other pain treatment in 24 h before the study start
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain measured using a visual analogue scale (VAS) at baseline, 2 weeks and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Physicians’ satisfaction with medication measured using the Physician Global Assessment (PGA) at 2 and 4 weeks | — |
Countries
Indonesia
Outcome results
None listed