Environmental hazards such as ambient air pollution, environmental tobacco smoke, water and food contaminants, noise, pesticides and ultraviolet light Other
Conditions
Interventions
WP1 (follow up with participants):
All participants approached are part of BiB and have taken part previously in HELIX. They have given consent to be contacted in the future. Participants will be cont
Sponsors
Bradford Royal Infirmary
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: WP 1: All participants (parents and children) that have consented and contributed to data collection in HELIX (n=231 families) WP7: 1. Parent with child in Year 5 or 6 (9-11 years old) attending participating school 2. Child able to follow air quality data collection protocol with support from teacher and parent 3. Parent able to give informed consent and child able to give verbal assent to the researcher
Exclusion criteria
Exclusion criteria: WP1: 1. Any participant that has consented and contributed to data collection in HELIX, but has withdrawn from the Born in Bradford cohort since or wishes to withdraw when approached for this follow-up 2. Any participant that has participated in HELIX and declines consent for Athlete WP7: 1. Parent does not give informed consent 2. Parent does not feel that the child will be able to operate the sensor or adhere to the data collection process
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| There is no singular outcome as WP1 will measure a host of personal and environmental exposures from personal monitoring, sensors, biosamples, and questionnaires. Similarly, there will be sensor data, questionnaires, and interviews for WP7 which will be used to describe environmental exposure. Measures occurring at the clinical examination visit: 1. Anthropometry for height and weight is measured using SECA scales and the Leister Height Measure d=1mm; waist circumference is measured using a flexible tape measure. These are measured at one point in time and can be conducted up to 7 days before baseline (the start of the monitoring period) or 7 days after blood collection. 2. Bioimpedance is measured using the Bodystat 1500NDD device at one point in time and can be conducted up to 7 days before baseline (the start of the monitoring period) or 7 days after blood collection. 3. Blood pressure is measured using the OMRON electronic 705-CP11 device at one point in time and can be conducted up to 7 days before baseline (the start of the monitoring period) or 7 days after blood collection. 4. Spirometry is measured using the EasyOne spirometry device at one point in time and can be conducted up to 7 days before baseline (the start of the monitoring period) or 7 days after blood collection. 5. Neurodevelopment is measured using the N-back test (working memory), Roulettes task (risk-taking preferences), and Raven Standard Progressive Matrices (non-verbal general intelligence). These are computerized tasks that are conducted at one point in time and can be conducted up to 7 days before baseline (the start of the monitoring period) or 7 days after blood collection. Biological samples: 1. Environmental exposures measured from hair (50 mg or ~1 cm² of scalp area) collected close to the scalp using scissors at one point in time and can be conducted at any time relative to the baseline visit. 2. Phthalates measured from urine samples (collected using the Vitrex Vacusense 112510 k | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed