Not applicable Not Applicable Not applicable
Conditions
Interventions
Participants (both case and control groups) are identified using military records and are invited to participate through receiving a letter from their doctor’s office.
If veterans an
Sponsors
Brunel University London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Intervention group: 1. UK residents 2. Registered with a UK GP 3. Contactable by phone 4. Must be a veteran born in 1930 or later who participated in the nuclear testing programme 4.1. Be the wife or partner of the veteran and be registered at the same GP as the veteran 4.2. Veterans and participating partner must have a surviving child together who is resident and willing to take part in the study Control group: 1. UK residents 2. Registered with a UK GP 3. Contactable by phone 4. Must be a veteran born in 1930 or later who did not serve in the nuclear testing programme but did serve in a tropical location 4.1. Be the wife or partner of the veteran and be registered at the same GP as the veteran 4.2. Veterans and participating partner must have a surviving child together who is resident and willing to take part in the study
Exclusion criteria
Exclusion criteria: Veterans and participating children: 1. Been diagnosed with cancer (other than non-melanoma skin cancer) 2. Have had cytotoxic chemotherapy or radiation treatment for any reason (such as methotrexate for rheumatoid arthritis) All participants: 1. Compromises the participant safety or compliance as judged by a GP
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytogenetic evidence of differences in the frequency and spectra of chromosome aberrations in male nuclear test veterans and/or their children is assessed using a range of chromosomal assays by taking a blood sample. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Future genetic and cytogenetic assessments of familiy groups will be assessed using stored DNA and isolated blood cells from blood samples 2. Long-term health status is followed up through national registers for death and cancer registration and hospital admissions via Hospital Episode Statistics | — |
Countries
England, United Kingdom
Outcome results
None listed