HNPCC-associated colorectal carcinoma Cancer Colorectal
Conditions
Interventions
Subtotal colectomy vs. oncologic resection (restorative proctocolectomy vs rectum resection/extirpation)
Sponsors
Deutsche Krebshilfe e. V. - German Cancer Aid (Germany)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Colorectal carcinoma fulfilling the Amsterdam-criteria for HNPCC or 2. Colorectal carcinoma in patients with known pathogenic mismatch repair gene mutation or 3. Colorectal carcinoma at the age of 50 or less and detection of microsatellite instability in a tumor biopsy and 4. Age between 18 and 65 years 5. Operability for subtotal colectomy/(restorative) proctocolectomy as estimated by the surgeon 6. Exclusion of metastases, local resection of the complete tumor likely to be possible 7. Elective tumorsurgical operation 8. Willingness of the patient to participate in surveillance required by the trial 9. Informed consent
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Germany
Outcome results
None listed