‘iCam’ polymerase chain reaction (PCR) testing for rapid diagnosis of eye infections

‘iCam’ PCR microarray for microbial diagnosis of infectious keratitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17422545

Enrollment

Registered

2023-01-26

Start date

2021-09-22

Completion date

Unknown

Last updated

2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diagnosis of microbial keratitis/endophthalmitis Eye Diseases

Interventions

Corneal scrapes or vitreous biopsies are taken from patients after instillation of topical anaesthetic eye drops (e.g. proxymetacaine/tetraine) with sterile needles/blades and placed in a transport me

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients, aged 18 years and above, presenting to eye department with a corneal ulcer or suspected endophthalmitis

Exclusion criteria

Exclusion criteria: Does not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame
Microbial detection using PCR and conventional culture techniques. The measure is the positive identification of the microbe in the suspected cases of ocular infection. Measured at a single time point.	—

Secondary

Measure	Time frame
Ct values (threshold cycle) at time of running array card.	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 4, 2026