Establishing spinal cord imaging biomarkers in people with recently diagnosed multiple sclerosis Nervous System Diseases
Conditions
Interventions
The pilot study will have two time points: baseline and 6-month follow-up. At each time point, a participant will undergo a 1-hour spinal cord MRI scan, including structural and advanced MRI sequences
Sponsors
University of Edinburgh
NHS Lothian
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Recent diagnosis of relapsing-remitting multiple sclerosis (<6 months) 2. Aged 18 years or older 3. Capacity to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Intake of disease-modifying treatments prescribed prior to baseline assessment 2. Participation in an interventional clinical trial prior to baseline assessment 3. Contraindications for MRI 4. Other neurological disorders 5. History of spinal injury
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spinal cord atrophy, lesions and microstructure will be measured using spinal cord magnetic resonance imaging at baseline and 6-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical disability will be measured using the Expanded-Disability Status Scale (EDSS), Nine-Hole Peg Test (9-HPT) and Timed 25-Foot Walk test (T25-FW) at baseline and 6-month follow-up | — |
Countries
Scotland, United Kingdom
Contacts
Public ContactRozanna Meijboom
Outcome results
None listed