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High-flow nasal oxygen (HFNO) in high-risk cardiac surgical patients

A randomised controlled trial of high-flow nasal oxygen (Optiflow™) and standard oxygen therapy in high-risk patients after cardiac surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN17399068
Enrollment
74
Registered
2015-07-16
Start date
2015-09-01
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Cardiovascular disease

Interventions

Before surgery, each participant performs a six-minute walking test under the supervision of a physiotherapist. This simple test measures how far patients can walk in six minutes. Additionally, patien

Sponsors

Papworth Hospital NHS Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged over 18 years 2. Undergoing elective cardiac surgery (coronary artery bypass grafting, valve surgery or both) 3. One or more patient related risk factor for postoperative pulmonary complications (COPD, asthma, lower respiratory tract infection in last 4 weeks, body mass index=35 kg/m2 current (last 6 weeks) heavy smokers (> 10 pack years)) 4. Capable of performing a 6MWT. The 6MWT is a clinical exercise test, and is popular in clinical practice because it aids clinical decision making, and because of the belief that it provides a better estimate of functional capacity than resting cardiorespiratory measurements. The 6MWT is the most popular clinical exercise test, which is used for postoperative evaluation after lung surgery and has also been validated in cardiac surgery

Exclusion criteria

Exclusion criteria: 1. Contraindication to high flow nasal oxygen such as nasal septal defect 2. Not met extubation criteria by 10am the day after surgery (Day 1) 3. Need for CPAP preoperatively

Design outcomes

Primary

MeasureTime frame
Hospital length of stay (days)

Secondary

MeasureTime frame
1. Early postoperative functional recovery, determined by 6 minute walk test (6MWT) 2. Early postoperative lung function, tested by spirometry 3. Intensive care unit (ICU) length of stay (days) 4. Requirement for escalation of respiratory support and ICU re-admission

Countries

United Kingdom

Contacts

Public ContactFiona Bottrill

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026