Can a drug that improves blood flow and oxygen supply to the heart improve outcomes during and after heart surgery?

Esmolol vs dexmedetomidine for attenuation of haemodynamic responses in patients undergoing elective off-pump coronary artery bypass grafting: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17397629

Enrollment

Registered

2019-06-24

Start date

2014-03-01

Completion date

Unknown

Last updated

2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure Circulatory System Heart failure

Interventions

A controlled clinical study in patients undergoing elective coronary revascularization during off pump coronary artery bypass grafting, under standardized general anesthesia. Randomly received infusio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged over 18 years 2. Off-pump cardiac surgery 3. Left ventricular ejection fraction =40% 4. New York Heart Association classification III-IV 4. IC =2.5 L 5. American Society of Anaesthesiologists (ASA) physical status classification II or III

Exclusion criteria

Exclusion criteria: 1. Patients with liver or kidney failure. 2. Patients requiring coronary revascularization with extracorporeal circulation. 3. Candidates for cardiac reoperation. 4. Patients with hemodynamic instability, cardiogenic shock.

Design outcomes

Primary

Measure	Time frame
1. Heart failure is recorded if CI <2.0 L/minm2 up to 48 hours postoperatively. 2. Low cardiac output defined 2 L/min/m2. Cardiac index is calculated from cardiac output, which is measured using the thermodilution technique via the Swan-Ganz catheter up to 48 hours postoperatively.	—

Secondary

Measure	Time frame
1. Central venous pressure will be assessed using a pulmonary artery catheter at were stratified by quartiles of mean CVP during the first 48 hours after ICU admission. 2. Pulmonary capillary wedge pressure will be assessed using a pulmonary artery catheter. The changes in the pulmonary circulation in 20 cardiac surgery patients undergoing off pump coronary artery bypass grafting. 3. Low systemic vascular resistance during cardiac surgery will be assessed using a pulmonary artery catheter, and vigileo monitor for data outcome variables. 4. Diference in perioperative arterial blood preassure measered by Arterial blood pressure will be assessed using an arterial radial catheter during the first 48 h after ICU admission. 5. Mixed venous oxygen saturation (SVO2) will be assessed by analysis of blood gases by vigileo monitor. 6. Variables of haemodynamics monitoring by Vigileo Monitor EDWARDS LIFESCIENCES, in cardiac surgery patients undergoing off pump coronary artery bypass grafting, moniroring cardiac output, surgical patients requiring continuous invasive monitoring during ICU stay. Start in induction of anaesthesia, sternotomy, grafting of coronary descending, post-revascularization and 48 h after ICU. 7. Laboratory results related to organ dysfunction and the length of ICU admission and hospitalization.	—

Measure

Time frame

1. Central venous pressure will be assessed using a pulmonary artery catheter at were stratified by quartiles of mean CVP during the first 48 hours after ICU admission. 2. Pulmonary capillary wedge pressure will be assessed using a pulmonary artery catheter. The changes in the pulmonary circulation in 20 cardiac surgery patients undergoing off pump coronary artery bypass grafting. 3. Low systemic vascular resistance during cardiac surgery will be assessed using a pulmonary artery catheter, and vigileo monitor for data outcome variables. 4. Diference in perioperative arterial blood preassure measered by Arterial blood pressure will be assessed using an arterial radial catheter during the first 48 h after ICU admission. 5. Mixed venous oxygen saturation (SVO2) will be assessed by analysis of blood gases by vigileo monitor. 6. Variables of haemodynamics monitoring by Vigileo Monitor EDWARDS LIFESCIENCES, in cardiac surgery patients undergoing off pump coronary artery bypass grafting, moniroring cardiac output, surgical patients requiring continuous invasive monitoring during ICU stay. Start in induction of anaesthesia, sternotomy, grafting of coronary descending, post-revascularization and 48 h after ICU. 7. Laboratory results related to organ dysfunction and the length of ICU admission and hospitalization.

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Countries

Mexico

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026