Effective analgesia in patients after knee surgery

The impact of different techniques of analgesia on stress response in patients after total knee replacement

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17389296

Enrollment

120

Registered

2017-11-22

Start date

2015-10-15

Completion date

Unknown

Last updated

2017-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee replacement and pain Surgery Total knee replacement and pain

Interventions

Application of different type of postoperative analgesia (lubar epidraul analgesia, peripheral nerve blocks, and systemic multimodal analgesia) in patients after total knee replacement Participants w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who underwent elective surgery for primary degenerative osteoarthritis scheduled at Clinic of Orthopedics and Traumatology Lovran, Lovran, Croatia for total knee replacement (TKR), American Society of Anesthesiologists (ASA) physical status I to III 2. Fully able to understand the study contents were included in the study 3. Adults over 50

Exclusion criteria

Exclusion criteria: 1. Patients with allergies to anesthetics and analgesics 2. Received blood transfusion 3. Those with neurologic conditions of the lower limbs 4. Immune disorders 5. Malignant disease 6. Secondary form of knee osteoarthritis or rheumatoid arthritis

Design outcomes

Secondary

Measure	Time frame
1. Patient outcome is measured using hospital electronic documentation system at before surgery, after surgery, 24 hours and 72 hours after surgery 2. Complications is measured using hospital electronic documentation system at before surgery, after surgery, 24 hours and 72 hours after surgery	—

Primary

Measure	Time frame
1. Pain intensity is measured using the VAS at rest and on movement before surgery,after surgery, 24 hours and 72 hours after surgery 2. Absolute number of leukocytes is measured using electronic counter Technicom H-1 system, USA, using laser's optical principle of dark colors 3. Frequency of different types of lymphocytes is measured using the flow cytometry before surgery,after surgery, 24 hours and 72 hours after surgery 4. Concentration of cytokines and hormones are measured using ELISA before surgery, after surgery, 24 hours and 72 hours after surgery	—

Measure

Time frame

1. Pain intensity is measured using the VAS at rest and on movement before surgery,after surgery, 24 hours and 72 hours after surgery 2. Absolute number of leukocytes is measured using electronic counter Technicom H-1 system, USA, using laser's optical principle of dark colors 3. Frequency of different types of lymphocytes is measured using the flow cytometry before surgery,after surgery, 24 hours and 72 hours after surgery 4. Concentration of cytokines and hormones are measured using ELISA before surgery, after surgery, 24 hours and 72 hours after surgery

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Countries

Croatia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026