The effect of platelet-rich plasma and laser in reducing post-operative complications after lower third molar extraction

Reducing post-operative complications after impacted lower third molars surgical extraction using platelet-rich plasma (PRP) in combination with diode laser (660 nm). Randomized Controlled Trial (RCT)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17334706

Enrollment

Registered

2024-04-10

Start date

2022-04-03

Completion date

Unknown

Last updated

2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted lower third molars Oral Health

Interventions

This study is designed to compare the efficacy of platelet-rich plasma (PRP) in combination with diode laser, PRP alone, and a control group (no additional procedure as a control group) in minimizing

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged between 18-30 years old 2. Require extraction of impacted lower third molars (asymptomatic, bilateral and indicated extractions (poorly placed, orthodontic reasons) and symmetrical (the angle, and difficulty of extraction)) 3. Healthy patients that have no systemic diseases that may affect the healing process 4. The surgical condition should be as similar as possible among the group (e.g. extraction time) 5. Able to give consent to enroll in the study

Exclusion criteria

Exclusion criteria: 1. Pre-existing medical condition that is considered a surgery contraindication 2. Pregnancy and lactation 3. Allergies to some medication (Paracetamol, Chlorhexidine) 4. Severe TMJ disorders 5. Chronic or neurological pain, and psychological disorders 6. Light sensitivity

Design outcomes

Primary

Measure	Time frame
Pain measured using a Visual Analogue Scale (VAS) on the procedure day and daily on the first 7 days following the procedure	—

Secondary

Measure	Time frame
1. Edema measured using the tape method (the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible) at baseline, 3 days, and 7 days following the procedure 2. Healing index measured using the Gingival Healing Index (GHI) on one timepoint 7 days post-operatively 3. Trismus measured using the Maximum Interincisal Opening (MOI) at baseline, 3 days, and 7 days following the procedure	—

Measure

Time frame

1. Edema measured using the tape method (the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible) at baseline, 3 days, and 7 days following the procedure 2. Healing index measured using the Gingival Healing Index (GHI) on one timepoint 7 days post-operatively 3. Trismus measured using the Maximum Interincisal Opening (MOI) at baseline, 3 days, and 7 days following the procedure

—

Countries

Syria

Contacts

Public ContactRita;Rita Alsaleh;Alsaleh

;

rita1995.alsaleh@damascusuniversity.edu.sy;rorialsaleh@gmail.com+963934899782;+963934899782

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026