Specialty: Critical care, Primary sub-specialty: Critical care
Conditions
Interventions
All patients will be monitored during their stay in ICU up to five days from the first blood culture i.e. to the time of the final blood culture report. On the first day two blood samples will be take
Sponsors
University College London Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient has blood culture taken in critical care unit 2. Age >18 years 3. Not palliative treatment 4. Discharge expected within 48 hours 5. Death not imminent 6. Blood culture positive <12 hours 7. Test cannot be completed on the day sample taken
Exclusion criteria
Exclusion criteria: 1. Patient < 18 years of age 2. The treatment intent is palliative; the clinician is not committed to aggressive treatment 3. Treating clinician expects the patient to be discharged from the ICU on the day of evaluation (i.e. assessment for inclusion) or the following day 4. Death is deemed imminent and inevitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether the clinician’s decision on continuing antibiotic would have been affected by the test result if it had been available is assessed through clinician interviews at 24 and 48 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of defined daily doses of antibiotic that would have been saved if the clinician had decided to stop antibiotics upon receiving a negative test result is determined by reviewing the patient’s current antibiotic treatment and expected duration at 24 or 48 hours. | — |
Countries
United Kingdom
Outcome results
None listed