Reduction of oxidative stress in patients with type 2 diabetes via periodontal treatment and ozone therapy Oral Health
Conditions
Interventions
Subjects receive either periodontal treatment followed by up to 6 sessions of gaseous ozone therapy or periodontal therapy alone
Sponsors
Albanian University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the type 2 diabetes mellitus (T2DM) diagnostic criteria recommended by the American Diabetes Association (ADA) in 2020: 1.1. FPG =126 mg/dl (7.0 mmol/l), or 2-h PG =200 mg/dl (11.1 mmol/l) during OGTT, or HbA1C =6.5 % (48 mmol/mol), or a random plasma glucose =200 mg/dl (11.1 mmol/l) 2. Diagnosis of generalized periodontitis
Exclusion criteria
Exclusion criteria: 1. Declined cognitive function and unable to make informed consent 2. Underwent periodontal treatment within the last 12 months 3. Systemic antibiotic therapy within the last 6 months 4. Pregnancy or breastfeeding 5. Uncontrolled hypertension 6. History of heart disease or stroke which might interfere with the systemic antioxidative status 7. Active smokers (>10 cigarettes/daily)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxidative stress quantified as the total oxidant status (TOS), total antioxidant status (TAS), nitric oxide (NO) levels, malondialdehyde (MDA) levels, glutathione (L-?-glutamyl-L-cysteinyl-glycine, GSH) levels measured using a commercially available kit to derive in saliva and a spectrophotometric procedure in blood at baseline, 3, and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Periodontal depth (PD) measured using a periodontal probe at baseline, 3, and 6 months 2. Clinical attachment level (CAL) measured using a periodontal treatment at baseline, 3, and 6 months 3. Bleeding on Probing (BOP) measured using a periodontal probe at baseline, 3 and 6 months | — |
Countries
Albania
Outcome results
None listed