Perioperative complications and autonomic function assessed by the COMPASS-31 tool

Perioperative complications and autonomic function assessed by the COMPASS-31 tool: multicentre, observational, mechanistic cohort study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17277871

Enrollment

296

Registered

2025-12-18

Start date

2025-11-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autonomic function in people undergoing major noncardiac surgery under general anaesthesia Nervous System Diseases

Interventions

Composite Autonomic Symptom Score-31 within 30 days after surgery.

Eligibility

Sex/Gender

All

Age

50 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged = 50 years and over undergoing elective major noncardiac surgery under general anaesthesia expected to require at least an overnight stay in hospital.

Exclusion criteria

Exclusion criteria: 1. Lack of capacity or refusal to provide written informed consent 2. Inability to complete questionnaires 2. American Society of Anesthesiologists (ASA) score of I

Design outcomes

Primary

Measure	Time frame
Autonomic function measured using the Composite Autonomic Symptom Score-31 (COMPASS-31) score at baseline before surgery	—

Secondary

Measure	Time frame
Individual components of the COMPASS-31 questionnaire assessing autonomic function: orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor abnormalities collected prior to the participant undergoing surgery.	—

Countries

England, United Kingdom

Contacts

Public ContactPriyanthi;Ahmed Dias;Alotaibi

;

p.dias@qmul.ac.uk;a.a.alotaibi@qmul.ac.uk+44 (0)2035940349;+44 (0)77 7881 9527

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 10, 2026