Does muscle strength and abdominal wall function improve with weight loss after gastric bypass?

Does muscle strength and abdominal wall function improve with weight loss after gastric bypass? A clinical observational study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17263619

Enrollment

100

Registered

2017-03-15

Start date

2016-09-30

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, weight loss, muscle strength Nutritional, Metabolic, Endocrine Obesity

Interventions

Current interventions as of 11/09/2025: Blood samples are collected to analyze matrix metalloproteinases, hyaluron och associated biomarkers before surgery, as well as 1 month, 3 months, 6 months, p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients eligible for primary laparoscopic gastric bypass 2. All patients undergoing primary laparoscopic gastric bypass at Lycksele Hospital are eligible for recruitment 3. Patients undergoing surgery in Uppsala are eligible for collection of blood and tissue samples only 4. All ages

Exclusion criteria

Exclusion criteria: If, after inclusion, no or different surgery is planned

Design outcomes

Primary

Measure	Time frame
Current primary outcome measure as of 11/09/2025: 1. Matrix metalloproteinases, hyaluron and associated biomarkers measured from blood samples taken at baseline (pre-operatively) and 1 month, 3 months, 6 months, and 2 and 3 years postoperatively 2. Abdominal wall and thigh muscle strength, measured with the BioDex System 3 at baseline (pre-operatively), 6 months and 3-6 years postoperatively 3. Physical ability and abdominal wall function, measured using the Ventral Hernia Pain Questionnaire (VHPQ), International Physical Activity Questionnaire (IPAQ), and Visual Analog Scale (VAS) for abdominal wall function at baseline (pre-operatively), 6 months and 3-6 years postoperatively 4. Semi-structured interviews describing the change in muscle strength, physical activity ability and abdominal wall function after gastric bypass surgery 5. Change in external (EAS) and internal anal sphincter (IAS) measured with endoanal ultrasound before and 6 months postoperatively, with incontinence and urgency measured with Wexner Score and Low Anterior Resection Syndrome (LARS). _____ Previous primary outcome measure as of 13/12/2023: 1. Matrix metalloproteinases, hyaluron and associated biomarkers measured from blood samples taken at baseline (pre-operatively) and 1 month, 3 months, 6 months, and 2 and 3 years postoperatively 2. Abdominal wall and thigh muscle strength, measured with the BioDex System 3 at baseline (pre-operatively), 6 months and 3-6 years postoperatively 3. Physical ability and abdominal wall function, measured using the Ventral Hernia Pain Questionnaire (VHPQ), International Physical Activity Questionnaire (IPAQ), and Visual Analog Scale (VAS) for abdominal wall function at baseline (pre-operatively), 6 months and 3-6 years postoperatively 4. Semi-structured interviews describing the change in muscle strength, physical activity ability and abdominal wall function after gastric bypass surgery _____ Previous primary outcome measure as of 03/03/2022: 1. Matrix m	—

Measure

Time frame

Current primary outcome measure as of 11/09/2025: 1. Matrix metalloproteinases, hyaluron and associated biomarkers measured from blood samples taken at baseline (pre-operatively) and 1 month, 3 months, 6 months, and 2 and 3 years postoperatively 2. Abdominal wall and thigh muscle strength, measured with the BioDex System 3 at baseline (pre-operatively), 6 months and 3-6 years postoperatively 3. Physical ability and abdominal wall function, measured using the Ventral Hernia Pain Questionnaire (VHPQ), International Physical Activity Questionnaire (IPAQ), and Visual Analog Scale (VAS) for abdominal wall function at baseline (pre-operatively), 6 months and 3-6 years postoperatively 4. Semi-structured interviews describing the change in muscle strength, physical activity ability and abdominal wall function after gastric bypass surgery 5. Change in external (EAS) and internal anal sphincter (IAS) measured with endoanal ultrasound before and 6 months postoperatively, with incontinence and urgency measured with Wexner Score and Low Anterior Resection Syndrome (LARS). _____ Previous primary outcome measure as of 13/12/2023: 1. Matrix metalloproteinases, hyaluron and associated biomarkers measured from blood samples taken at baseline (pre-operatively) and 1 month, 3 months, 6 months, and 2 and 3 years postoperatively 2. Abdominal wall and thigh muscle strength, measured with the BioDex System 3 at baseline (pre-operatively), 6 months and 3-6 years postoperatively 3. Physical ability and abdominal wall function, measured using the Ventral Hernia Pain Questionnaire (VHPQ), International Physical Activity Questionnaire (IPAQ), and Visual Analog Scale (VAS) for abdominal wall function at baseline (pre-operatively), 6 months and 3-6 years postoperatively 4. Semi-structured interviews describing the change in muscle strength, physical activity ability and abdominal wall function after gastric bypass surgery _____ Previous primary outcome measure as of 03/03/2022: 1. Matrix m

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Sweden

Contacts

Public ContactJeff Wennerlund

Jeff.Wennerlund@umu.se+46 (0)950 39124

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026