Comparison of three nerve block techniques on postoperative pain and recovery after modified radical mastectomy

A randomized controlled trial comparing the effects of erector spinae plane block, thoracic paravertebral block, and pectoral nerve block on postoperative analgesia and Quality of Recovery-15 in patients undergoing modified radical mastectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17247698

Enrollment

Registered

2025-11-07

Start date

2021-05-15

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer Cancer

Interventions

A computer-generated randomization sequence was used for participant allocation into three intervention groups (ESPB, TPVB, and PECS), and group assignments were concealed using sealed opaque envelope

Eligibility

Sex/Gender

Female

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status I–II 2. Scheduled for unilateral modified radical mastectomy

Exclusion criteria

Exclusion criteria: 1. Obesity 2. Previous breast surgery 3. Bleeding disorders 4. Allergies to study drugs 5. Anticoagulant or chronic analgesic use 6. Severe cardiac, hepatic, or renal disease

Design outcomes

Primary

Measure	Time frame
Total morphine consumption (mg) measured using the patient-controlled analgesia (PCA) device at 24 hours postoperatively	—

Secondary

Measure	Time frame
1. Time to first morphine request, recorded from arrival in recovery until the first PCA morphine dose request (minutes) 2. Postoperative pain intensity, measured using the Visual Analog Scale (VAS) at 0, 1, 3, 6, 12, and 24 hours at rest and during movement 3. Quality of Recovery, assessed using the Quality of Recovery-15 (QoR-15) questionnaire at 24 hours postoperatively 4. Incidence of rescue fentanyl administration, based on VAS =4, within the first 24 hours 5. Incidence of postoperative nausea and vomiting (PONV) within 24 hours, recorded as present or absent 6. Patient satisfaction with analgesia, assessed at 24 hours using a 5-point Likert scale	—

Measure

Time frame

1. Time to first morphine request, recorded from arrival in recovery until the first PCA morphine dose request (minutes) 2. Postoperative pain intensity, measured using the Visual Analog Scale (VAS) at 0, 1, 3, 6, 12, and 24 hours at rest and during movement 3. Quality of Recovery, assessed using the Quality of Recovery-15 (QoR-15) questionnaire at 24 hours postoperatively 4. Incidence of rescue fentanyl administration, based on VAS =4, within the first 24 hours 5. Incidence of postoperative nausea and vomiting (PONV) within 24 hours, recorded as present or absent 6. Patient satisfaction with analgesia, assessed at 24 hours using a 5-point Likert scale

—

Countries

Türkiye

Contacts

Public ContactBilal Atilla Bezen

drbilalatilla@gmail.com+90 (0)5419671370

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 29, 2026