The impact of obesity and weight loss on the endometrium

The impact of obesity and weight loss on the endometrium: a prospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17241389

Enrollment

150

Registered

2014-04-23

Start date

2012-04-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial cancer Cancer Endometrial cancer

Interventions

Medical history, height and weight (to calculate BMI) hip and waist measurements a blood sample and an endometrial biopsy will be taken at the baseline clinic visit. At 6 weeks and 9-12 months post-s

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female aged 18 years or more 2. Undergoing bariatric surgery or commencing medical weight management therapy 3. Written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: 1. Previous hysterectomy 2. Intrauterine device (IUD) or levonorgestrel intrauterine system (LNG-IUS) in situ 3. Previous endometrial ablation 4. Treatment with tamoxifen 5. Pregnancy

Design outcomes

Primary

Measure	Time frame
Ki67 expression by the endometrium (a marker of proliferation) measured at baseline and post weight loss (endometrial biopsy).	—

Secondary

Measure	Time frame
Endometrial markers, physiological markers and changes in menstrual function and mental wellbeing measured at baseline and post weight loss (blood sample and questionnaire).	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026